SSR-P Clinical Efficacy

SSR-P Clinical Mechanism of Action

SSR-P 12.5 a Paroxetine 12.5 mg prolonged release, Selective Serotonin Reuptake Inhibitor (SSRI) that primarily works by inhibiting the immediate reuptake of serotonin in the brain thereby making it more available.

1. Serotonin Reuptake Inhibition: SSR-P selectively inhibits the serotonin transporter (SERT), which is responsible for the reuptake of serotonin from the synaptic cleft back into the presynaptic neuron. By blocking this transporter, paroxetine increases the concentration of serotonin in the synaptic cleft.

2. Enhanced Serotonergic Activity: The increased serotonin levels enhance serotonergic neurotransmission, which is crucial for regulating mood, anxiety, and other functions. This enhancement helps alleviate symptoms of depression, anxiety disorders, obsessive-compulsive disorder (OCD), and other related conditions.

3. Binding to Serotonin Receptors: SSR-P binds to various serotonin receptors, including 5-HT1A, 5-HT2A, and 5-HT2C receptors. This binding further modulates the serotonergic system and contributes to its therapeutic effects.

4. Pharmacodynamic Effects: The pharmacodynamic effects of SSR-P include improved mood, reduced anxiety, and decreased obsessive-compulsive behaviours. It also helps manage symptoms of PTSD and menopausal hot flashes.

5. Clinical Efficacy: SSR-P 12.5 has been shown to be effective in clinical trials for treating major depressive disorder, generalized anxiety disorder, social phobia, panic disorder, OCD, and PTSD. Its efficacy is attributed to its potent and selective inhibition of serotonin reuptake1.

6. Side Effects: SSR-P specially formulated for its reduced symptoms of side effects may include nausea, dizziness, sexual dysfunction, and weight gain in higher doses. These side effects are generally manageable and tend to diminish over time.

SSR-P is not typically considered a habit-forming medication, but it is important to take SSR-P exactly as prescribed by your doctor and do not overuse or misuse. If you have any concerns about your medication, it's best to discuss them with your healthcare provider.

Off label uses of SSR-P (to be prescribed by a Doctor only)

SSR-Pis used off-label for several conditions beyond its approved uses. Here are some common off-label applications:

1. Premenstrual Dysphoric Disorder (PMDD): Helps alleviate severe emotional and physical symptoms associated with PMDD.

2. Irritable Bowel Syndrome (IBS): Can reduce symptoms of IBS, particularly in patients with diarrhea-predominant IBS.

3. Bipolar Depression: Sometimes prescribed to manage depressive episodes in bipolar disorder.

4. Body Dysmorphic Disorder (BDD): Used to treat obsessive concerns about perceived physical flaws.

5. Impulse Control Disorders: Helps manage conditions like kleptomania, pyromania, and pathological gambling.

6. Premature Ejaculation (PE): Effective in delaying ejaculation and improving sexual satisfaction.

SSR-P is a pharmaceutical medicine and should not be taken without a doctor's prescription by self diagnosis or self medication.